Tissue Allograft Therapy for Arthritis

Osteoarthritis – often just called arthritis – is considered the 4th leading cause of disability in the world, and is the number one cause of disability in the U.S. affecting over 50 million people annually. Arthritis is considered “joint inflammation” where joints get inflamed and degenerate due to a variety of reasons and can cause severe pain and discomfort to those experiencing it.  Currently, there’s no cure for arthritis, it’s one of those diseases where physicians recommend treatments to help slow down the breakdown of the connective tissue and manage the pain. Traditional treatments for arthritis include anti-inflammatory and pain medication, physical therapy, and steroid injections directly into the joints.  These treatment options have produced mixed results, and there’s a significant demand by patients for non-traditional options. This is where regenerative medicine, and specifically tissue allograft therapy for arthritis, have come onto the medical scene with potentially life-changing results. 

Understanding Tissue Allograft Therapy for Arthritis

Tissue allograft therapy is the process of using allografts to help the body naturally restore, repair, and even replace damaged tissue. 

Tissue allograft therapy has been shown in studies to help regenerate damaged tissue due to two primary reasons: 

  1. Inflammation Reduction
  2. Paracrine Signaling

Inflammation Reduction

If your body is injured, whether it’s from a trauma or from a disease like arthritis, it will produce inflammation as a way of signaling for the healing process to begin. In fact, it’s a necessary process for healing, but inflammation becomes a problem within the body if it does not go away and becomes chronic. This is the case with arthritis which is chronic inflammation in the joints, wearing down the cartilage. There is substantive evidence where introducing tissue allografts into an inflamed joint can signal cytokines and growth factors to decrease the inflammation response, which allows for the joint to have an opportunity to begin healing itself. 

Paracrine Signaling

Another interesting effect of tissue allograft therapy is an occurrence of paracrine signaling. There has been evidence indicating an effect where damaged tissue which gets introduced to tissue allografts are signaled to begin the process of regeneration and reduction of the inflammation.   

Allogeneic Tissue Therapy

In this approach, tissue allografts are donated from a healthy individual for use by the patient. The tissue allograft is carefully screened, processed, and stored. Allogeneic tissue therapy offers the advantage of immediate availability without the need for invasive tissue extraction from the patient. 

Benefits of Tissue Allograft Therapy for Arthritis

Tissue allograft therapy offers a range of benefits for an arthritis patient which include: 

  1. Reduction In Inflammation – it is known to help provide a reduction in inflammation, which can provide relief for patients grappling with chronic discomfort. 
  2. Cartilage Regeneration – it has a unique ability to help regenerate and provide support for connective tissue which can promote joint health. 
  3. Long-term relief – unlike conventional treatments that merely manage symptoms, tissue allograft therapy aims to tackle the underlying disease process, offering the prospect of sustained benefits.


Tissue allograft therapy holds significant promise as a treatment option for arthritis. With its ability to address the root causes of the disease and promote tissue regeneration, tissue allograft therapy offers new hope to patients who have previously struggled with limited treatment options. Ongoing research, clinical trials, and patient success stories underscore the positive impact and efficacy of this approach. As we continue to explore the full potential of tissue allograft therapy, we can look forward to a future where arthritis management is transformed, allowing individuals to regain mobility, alleviate pain, and experience enhanced overall well-being.

Frequently Asked Questions

What type of stem cells are used to treat arthritis?

Currently the most popular stem cell used for arthritis is mesenchymal stem cells (MSCs).

How painful is stem cell therapy?

Stem cell injections to almost all body regions are generally no more discomforting compared to any other type of soft tissue injection.